Xeomin Treatments

Xeomin is an FDA-approved neuromodulator used to temporarily relax the muscles responsible for dynamic wrinkles — particularly the frown lines between the eyebrows, the horizontal lines across the forehead, and the crow’s feet at the corners of the eyes. Like Botox and Dysport, Xeomin contains a precisely calibrated form of botulinum toxin type A; unlike its counterparts, Xeomin is manufactured through a unique purification process that removes the accessory proteins typically found in other neuromodulator formulations. This “naked” toxin has the advantage of reducing the likelihood that the body will develop antibodies that gradually neutralize the treatment over time — a meaningful benefit for patients who have used neuromodulators for years and have noticed diminishing results. Xeomin is one of several injectables and fillers offered at Dr. Khosh’s Manhattan practice.

Whether a patient is new to neuromodulators or switching from another product, the precision of the injection matters as much as the product itself. Dr. Maurice Khosh’s approach to Xeomin is grounded in a deep academic understanding of facial musculature and three decades of clinical experience. Dual board-certified by the American Board of Facial Plastic and Reconstructive Surgery and the American Board of Otolaryngology–Head and Neck Surgery, he earned his medical degree from Albert Einstein College of Medicine, where he was inducted into the Alpha Omega Alpha (AOA) Medical Honor Society. He completed residency at Columbia University and a facial plastic surgery fellowship at the University of Washington. Dr. Khosh is a Fellow of the American College of Surgeons (FACS) and was the youngest recipient of Columbia University Medical Center’s Maxwell Abramson Resident Teaching Award. With thirty years of operating on facial muscles and nerves, he brings anatomical precision to every injection — calibrating dose and placement to soften unwanted lines without compromising natural expression.

What Xeomin Best Addresses

Xeomin is most effective for softening dynamic wrinkles — the lines that develop and deepen from repeated facial expressions. Dr. Khosh uses Xeomin to address a range of concerns where neuromodulator placement is the right approach:

• Glabellar Frown Lines: The vertical “11” lines between the eyebrows that develop from repeated frowning
• Horizontal Forehead Lines: The horizontal creases that form across the forehead from raising the eyebrows
• Crow’s Feet: The fine lines that radiate outward from the corners of the eyes when smiling or squinting
• Bunny Lines: The small diagonal wrinkles that appear across the bridge of the nose when scrunching the face
• Brow Position: Carefully placed Xeomin can produce a subtle, natural elevation of the outer brow
• Patients with Botox Resistance: An alternative for patients whose results from other neuromodulators have diminished over time

How Xeomin Differs from Other Neuromodulators

While Botox, Dysport, and Xeomin all temporarily relax facial muscles to soften wrinkles, each formulation has distinct characteristics. Xeomin’s purification process removes the complexing proteins that are present in Botox and Dysport — proteins that the immune system can occasionally recognize and produce antibodies against over years of use. For patients who have developed reduced response to Botox or Dysport, switching to Xeomin can sometimes restore the original effect. Onset time and duration are comparable to Botox: most patients see results within three to seven days, with the full effect lasting three to four months. Xeomin is FDA-approved for moderate to severe glabellar lines in adults, with off-label use for other dynamic wrinkle patterns. Choosing between Xeomin, Botox, and Dysport is a matter of patient history, treatment goals, and the specific injection pattern needed — not a question of which neuromodulator is universally better.

“The unique value of Xeomin is for patients who have developed reduced response to other neuromodulators over time — the purified formulation often restores the original effect. But for any patient, the most important variable isn’t which product is chosen. It’s the precision of the dose and placement.” — Dr. Maurice Khosh

Schedule Your Consultation in Manhattan

Xeomin may be the right choice for patients seeking natural-looking softening of moderate to severe frown lines, forehead wrinkles, or crow’s feet — and for patients whose results from other neuromodulators have diminished over time. The right outcome depends on accurate evaluation of muscle activity, careful product selection, and precise injection placement. To schedule a consultation at Dr. Khosh’s Park Avenue office in New York City, call (212) 339-9988 or contact us online to request an appointment.