Restylane Refyne
Restylane Refyne is the more flexible counterpart to Restylane Defyne — a hyaluronic acid filler engineered specifically for moderate facial lines and folds in areas where preserving natural expression is essential. Like Defyne, Refyne uses Galderma’s proprietary XpresHAn Technology™, but with a lighter, more pliable cross-linking pattern designed for less aggressive correction. The result is gentle smoothing of moderate nasolabial folds, marionette lines, and other perioral lines, with a soft, natural-feeling result that moves with the face rather than against it. FDA-approved for moderate to severe nasolabial folds and marionette lines, Refyne offers a meaningful refinement option for patients who want subtle improvement without the firmer feel of more robust fillers. Restylane Refyne is one of several formulations within the Restylane family, all offered as part of the broader injectables and fillers options at Dr. Khosh’s Manhattan practice.
Choosing between Refyne and the firmer Restylane formulations requires both product expertise and an aesthetic eye for how each patient’s face moves. Dr. Maurice Khosh brings both. Dual board-certified by the American Board of Facial Plastic and Reconstructive Surgery and the American Board of Otolaryngology–Head and Neck Surgery, Dr. Khosh is a Fellow of the American College of Surgeons (FACS) and a past president of the New York Facial Plastic Surgery Society. He has served on the American Academy of Facial Plastic and Reconstructive Surgery’s Board Examination and Continuing Education Committees, contributing to the national standards of practice in his field. With three decades of experience across the full range of injectable filler products — and an unwavering preference for natural, expression-preserving results — Dr. Khosh evaluates each patient individually to determine which Restylane formula will deliver the most refined outcome. He is a perennial Castle Connolly Top Doctor and Best Doctors in America honoree.
What Restylane Refyne Best Addresses
Restylane Refyne is most effective for moderate folds and lines where flexibility and subtle correction are the priority. Dr. Khosh uses Refyne to address a range of aesthetic concerns where natural movement matters as much as smoothing:
- Moderate Nasolabial Folds: Softening the lines between the corners of the nose and mouth without restricting natural smile mechanics
- Moderate Marionette Lines: Gentle correction of the lines that develop from the corners of the mouth toward the chin
- Mild to Moderate Perioral Lines: Smoothing fine lines around the mouth that resist topical treatments
- Subtle Lip Border Definition: Refining the vermillion border and re-establishing softer lip definition
- Early Facial Folds: Patients in earlier stages of aging who want refinement rather than dramatic correction
Refyne vs. Defyne: How They Differ
Although both Refyne and Defyne use the same XpresHAn Technology platform, the two products are formulated for different depths of correction. Refyne uses a softer, more flexible gel ideal for moderate folds and patients who want subtle, expression-preserving results. Defyne uses a firmer, more robust gel designed for deeper folds that require more structural support. During consultation, Dr. Khosh evaluates the depth of each fold, the activity of the surrounding muscles, and the patient’s overall facial proportions to determine which product — or combination — will produce the most natural result. Results from Refyne typically last up to a year, and like all hyaluronic acid fillers, the product can be dissolved with hyaluronidase if the outcome needs to be adjusted.
“Refyne and Defyne are two sides of the same technology — designed to do the same job at different depths. The art of using them well is matching the product to the fold rather than forcing one product into both situations. Subtle judgment around volume and depth is what makes the result look like the patient, only refreshed.” — Dr. Maurice Khosh
Schedule Your Consultation in Manhattan
Restylane Refyne may be the right choice for patients with moderate nasolabial folds, marionette lines, or perioral wrinkles who want gentle smoothing without sacrificing natural facial expression. The right outcome depends on accurate evaluation of fold depth, underlying muscle activity, and matching the correct Restylane formula to your individual anatomy. To schedule a consultation at Dr. Khosh’s Park Avenue office in New York City, call (212) 339-9988 or contact us online to request an appointment.
